Selected Publications

home page statistics

Home

Interests

Research Lab

Publications

Courses

Favorite

About Me

Feedback

 

 

Peer-Reviewed Publications (reverse chronological): {Note: The total citation number for English publications is 7408, updated on August 28, 2024 from Google Scholar. Click "Full-text" for the PDF file}.

  1. Banda A, Impomeni O, Singh A, Baloch AR, Hu W, Jaijyan DK. Precision in Action: The Role of Clustered Regularly Interspaced Short Palindromic Repeats/Cas in Gene Therapies. Vaccines (Basel). 2024 Jun 7;12(6):636. PMID: 38932365; PMCID: PMC11209408.
  2. Cueto R, Shen W, Liu L, Wang X, Wu S, Mohsin S, Yang L, Khan M, Hu W, Snyder N, Wu Q, Ji Y, Yang XF, Wang H. SAH is a major metabolic sensor mediating worsening metabolic crosstalk in metabolic syndrome. Redox Biol. 2024 Jul;73:103139. doi: 10.1016/j.redox.2024.103139. Epub 2024 Apr 27.
  3. Ma MT, Jiang Q, Chen C-H, Badeti S, Wang X, Zeng C, Evans D, Bodnar B, Marras SAE, Tyagi S, Bharaj P, Yehia G, Romanienko P, Hu W, Liu S-L, Shi L, Liu D. S309-CAR-NK cells bind the Omicron variants in vitro and reduce SARS-CoV-2 viral loads in humanized ACE2-NSG mice. J Virol. 2024 Jun 13;98(6):e0003824. doi: 10.1128/jvi.00038-24. Epub 2024 May 20.
  4. Wang P, Liu JB, Wang X, Meng FZ, Xiao QH, Liu L, Zhu J, Hu WH, Ho WZ. Activation of Toll-like receptor 3 inhibits HIV infection of human iPSC-derived microglia. J Med Virol. 2023 Nov;95(11):e29217. doi: 10.1002/jmv.29217.
  5. Ubba V, Joseph S, Awe O, Jones D, Dsilva MK, Feng M, Wang J, Fu X, Akbar RJ, Bodnar BH, Hu W, Wang H, Yang X, Yang L, Yang P, Ahima R, Divall S, Wu S. Neuronal AR Regulates Glucose Homeostasis and Energy Expenditure in Lean Female Mice With Androgen Excess. Endocrinology. 2023 Sep 23;164(11):bqad141. doi: 10.1210/endocr/bqad141.
  6. Wang X, Liu L, Jiang X, Saredy J, Xi H, Cueto R, Sigler D, Khan M, Wu S, Ji Y, Snyder NW, Hu W, Yang X, Wang H. Identification of methylation-regulated genes modulating microglial phagocytosis in hyperhomocysteinemia-exacerbated Alzheimer's disease. Alzheimers Res Ther. 2023 Oct 3;15(1):164. doi: 10.1186/s13195-023-01311-9.
  7. Guo Q, Xin M, Lu Q, Feng D, Yang V, Peng LF, Whelan KA, Hu W, Wu S, Yang X, Wang H, Rothberg BS, Gamero AM, Gerhard GS, Gao B, Yang L. A novel NEDD4L-TXNIP-CHOP axis in the pathogenesis of nonalcoholic steatohepatitis. Theranostics. 2023 Apr 9;13(7):2210-2225. doi: 10.7150/thno.81192. eCollection 2023.
  8. Guo ML, Roodsari SK, Cheng Y, Dempsey RE, Hu W. Microglia NLRP3 Inflammasome and Neuroimmune Signaling in Substance Use Disorders. Biomolecules. 2023 May 31;13(6):922. doi: 10.3390/biom13060922.
  9. Hu M, Bodnar B, Zhang Y, Xie F, Li F, Li S, Zhao J, Zhao R, Gedupoori N, Mo Y, Lin L, Li X, Meng W, Yang X, Wang H, Barbe MF, Srinivasan S, Bethea JR, Mo X, Xu H, Hu W. Defective neurite elongation and branching in Nibp/Trappc9 deficient zebrafish and mice. Int J Biol Sci. 2023 Jun 19;19(10):3226-3248. doi: 10.7150/ijbs.78489. eCollection 2023. (Full-Text)
  10. Wei Z, Bodnar B, Zhao RT, Xiao Q, Saribas S, Wang X, Ho WZ, Hu W. Human iPSC-derived brain organoids: A 3D mini-brain model for studying HIV infection. Exp Neurol. 2023 Mar 17;364:114386. doi: 10.1016/j.expneurol.2023.114386.
  11. Zhu Y, Saribas AS, Liu J, Lin Y, Bodnar B, Zhao R, Guo Q, Ting J, Wei Z, Ellis A, Li F, Wang X, Yang X, Wang H, Ho WZ, Yang L, Hu W. Protein expression/secretion boost by a novel unique 21-mer cis-regulatory motif (Exin21) via mRNA stabilization. Mol Ther. 2023 Feb 14:S1525-0016(23)00075-8. doi: 10.1016/j.ymthe.2023.02.012. (Full-Text)
  12. Drummer C 4th, Saaoud F, Jhala NC, Cueto R, Sun Y, Xu K, Shao Y, Lu Y, Shen H, Yang L, Zhou Y, Yu J, Wu S, Snyder NW, Hu W, Zhuo J', Zhong Y, Jiang X, Wang H, Yang X. Caspase-11 promotes high-fat diet-induced NAFLD by increasing glycolysis, OXPHOS, and pyroptosis in macrophages. Front Immunol. 2023 Jan 26;14:1113883. doi: 10.3389/fimmu.2023.1113883. eCollection 2023.
  13. Zhang B, Liu JB, Zhou L, Wang X, Khan S, Hu WH, Ho WZ. Cytosolic DNA sensor activation inhibits HIV infection of macrophages. J Med Virol. 2022 Oct 26:e28253. doi: 10.1002/jmv.28253.
  14. Lu Y, Sun Y, Xu K, Shao Y, Saaoud F, Snyder NW, Yang L, Yu J, Wu S, Hu W, Sun J, Wang H, Yang X. Editorial: Endothelial cells as innate immune cells. Front Immunol. 2022 Oct 4;13:1035497. doi: 10.3389/fimmu.2022.1035497. eCollection 2022
  15. Shan D, Qu P, Zhong C, He L, Zhang Q, Zhong G, Hu W, Feng Y, Yang S, Yang XF, Yu J. Anemoside B4 Inhibits Vascular Smooth Muscle Cell Proliferation, Migration, and Neointimal Hyperplasia. Front Cardiovasc Med. 2022 May 10;9:907490.
  16. Padhiar NH, Liu JB, Wang X, Wang XL, Bodnar BH, Khan S, Wang P, Khan AI, Luo JJ, Hu WH, Ho WZ. Comparison of BNT162b2-, mRNA-1273- and Ad26.COV2.S-Elicited IgG and Neutralizing Titers against SARS-CoV-2 and Its Variants.Vaccines (Basel). 2022 May 27;10(6):858
  17. Shah S, Wong LM, Ellis K, Bodnar B, Saribas S, Ting J, Wei Z, Tang Y, Wang X, Wang H, Ling B, Margolis DM, Garcia JV, Hu WH*, Jiang G. Microglia-Specific Promoter Activities of HEXB Gene. Frontiers in Cellular Neuroscience. 2022;16. doi: 10.3389/fncel.2022.808598. (Full-Text)
  18. Lu Y, Sun Y, Xu K, Saaoud F, Shao Y, Drummer C 4th, Wu S, Hu WH, Yu J, Kunapuli SP, Bethea JR, Vazquez-Padron RI, Sun J, Jiang X, Wang H, Yang X. Aorta in Pathologies May Function as an Immune Organ by Upregulating Secretomes for Immune and Vascular Cell Activation, Differentiation and Trans-Differentiation-Early Secretomes may Serve as Drivers for Trained Immunity. Front. Immunol.  2022 Mar 7;13:858256. doi: 10.3389/fimmu.2022.858256.
  19. Solis-Leal A, Siddiqui S, Wu F, Mohan M, Hu WH, Doyle-Meyers LA, Dufour JP, Ling B. Neuroinflammatory Profiling in SIV-Infected Chinese-Origin Rhesus Macaques on Antiretroviral Therapy. Viruses. 2022 Jan 13;14(1). doi: 10.3390/v14010139. PubMed PMID: 35062343; PubMed Central PMCID: PMC8781366. (1)
  20. Liu J, Bodnar BH, Padhiar NH, Khan AI, Meng F, Saribas S, Wang P, Wang X, McCluskey E, Shah S, Zhao H, Luo JJ, Hu WH*, Ho WZ. Correlation of vaccine-elicited antibody levels and neutralizing activities against SARS-CoV-2 and its variants. Clin Transl Med. 2021 Dec;11(12):e644. doi: 10.1002/ctm2.644. PubMed PMID: 34923762; PubMed Central PMCID: PMC8684769. (Full-Text)
  21. Liu Y, Meng FZ, Wang X, Wang P, Liu JB, Hu WH, Young WB, Ho WZ. Methamphetamine facilitates HIV infection of primary human monocytes through inhibiting cellular viral restriction factors. Cell Biosci. 2021 Nov 10;11(1):194. doi: 10.1186/s13578-021-00703-4. PubMed PMID: 34758885; PubMed Central PMCID: PMC8579418. (3)
  22. Liu J, Bodnar BH, Meng F, Khan AI, Wang X, Saribas S, Wang T, Lohani SC, Wang P, Wei Z, Luo J, Zhou L, Wu J, Luo G, Li Q, Hu WH*, Ho W. Epigallocatechin gallate from green tea effectively blocks infection of SARS-CoV-2 and new variants by inhibiting spike binding to ACE2 receptor. Cell Biosci. 2021 Aug 30;11(1):168. doi: 10.1186/s13578-021-00680-8. PubMed PMID: 34461999; PubMed Central PMCID: PMC8404181. (27)
  23. Liu M, Wu N, Xu K, Saaoud F, Vasilopoulos E, Shao Y, Zhang R, Wang J, Shen H, Yang WY, Lu Y, Sun Y, Drummer C 4th, Liu L, Li L, Hu WH, Yu J, Praticò D, Sun J, Jiang X, Wang H, Yang X. Organelle Crosstalk Regulators Are Regulated in Diseases, Tumors, and Regulatory T Cells: Novel Classification of Organelle Crosstalk Regulators. Front Cardiovasc Med. 2021;8:713170. doi: 10.3389/fcvm.2021.713170.
  24. Bodnar B, Patel K, Ho W, Luo JJ, Hu WH*. Cellular mechanisms underlying neurological/neuropsychiatric manifestations of COVID-19. J Med Virol. 2021 Apr;93(4):1983-1998. doi: 10.1002/jmv.26720. Epub 2020 Dec 23. PMID: 33300152; PMCID: PMC7897247. (IF 2.327 for 2020), (27)
  25. Shao DD, Meng FZ, Liu Y, Xu XQ, Wang X, Hu WH, Hou W, Ho WZ. Poly(dA:dT) Suppresses HSV-2 Infection of Human Cervical Epithelial Cells Through RIG-I Activation. Front Immunol. 2021 Feb 4;11:598884. doi: 10.3389/fimmu.2020.598884. PMID: 33664729; PMCID: PMC7923882. (IF 7.561 for 2020), (1)
  26. Xu XQ, Zhang B, Guo L, Liu Y, Meng FZ, Wang X, Hu WH, Khan AI, Ho WZ. Exosomes Transport Anti-Human Immunodeficiency Virus Factors from Human Cervical Epithelial Cells to Macrophages. J Innate Immun. 2021 Jun 3:1-11. doi: 10.1159/000514886. Epub ahead of print. PMID: 34082434. (IF 7.349 for 2020), (4)
  27. Ni D, Tang T, Lu Y, Xu K, Shao Y, Saaoud F, Saredy J, Liu L, Drummer C 4th, Sun Y, Hu WH, Lopez-Pastrana J, Luo JJ, Jiang X, Choi ET, Wang H, Yang X. Canonical Secretomes, Innate Immune Caspase-1-, 4/11-Gasdermin D Non-Canonical Secretomes and Exosomes May Contribute to Maintain Treg-Ness for Treg Immunosuppression, Tissue Repair and Modulate Anti-Tumor Immunity via ROS Pathways. Front Immunol. 2021 May 18;12:678201. doi: 10.3389/fimmu.2021.678201. PMID: 34084175; PMCID: PMC8168470. (IF 7.561 for 2020), (6)
  28. Bodnar B, Zhang Y, Liu J, Lin Y, Wang P, Wei Z, Saribas S, Zhu Y, Li F, Wang X, Yang W, Li Q, Ho WZ, Hu WH*. Novel Scalable and Simplified System to Generate Microglia-Containing Cerebral Organoids From Human Induced Pluripotent Stem Cells. Front Cell Neurosci. 2021 Jul 5;15:682272. doi: 10.3389/fncel.2021.682272. PMCID: PMC8288463. (IF 4.86 for 2020), (Full-text)
  29. Meng FZ, Liu JB, Wang X, Wang P, Hu WH, Hou W, Ho WZ. TLR7 Activation of Macrophages by Imiquimod Inhibits HIV Infection through Modulation of Viral Entry Cellular Factors. Biology (Basel). 2021 Jul 13;10(7):661. doi: 10.3390/biology10070661. PMID: 34356516; PMCID: PMC8301371. (IF 5.079 for 2020), (3)
  30. Liu M, Wu N, Xu K, Saaoud F, Vasilopoulos E, Shao Y, Zhang R, Wang J, Shen H, Yang WY, Lu Y, Sun Y, Drummer C 4th, Liu L, Li L, Hu WH, Yu J, Praticò D, Sun J, Jiang X, Wang H, Yang X. Organelle Crosstalk Regulators Are Regulated in Diseases, Tumors, and Regulatory T Cells: Novel Classification of Organelle Crosstalk Regulators. Front Cardiovasc Med. 2021 Jul 22;8:713170. doi: 10.3389/fcvm.2021.713170. PMID: 34368262; PMCID: PMC8339352. (IF 4.79 for 2020), (2)
  31. Fu H, Sun Y, Shao Y, Jaredy J, Cueto R, Lu L, Drummer C 4th, Johnson C, K Xu, Lu Y, Li X, Meng S, Xue E, Tan J, Jhala NC, Yu D, Zhou Y, Bayless K, Yu J, Rogers T, Hu WH, Snyder NW, Sun J, Qin X, Jiang X, Wang H, Yang X. Interleukin 35 delays hindlimb ischemia-induced angiogenesis through regulating ROS-extracellular matrix but spares later regenerative angiogenesis. Front. Immunol. | doi: 10.3389/fimmu.2020.595813 (IF 7.561 for 2020), (12)
  32. Guo P, Si M, Wu D, Xue HY, Hu WH, Wong HL. Incorporation of docosahexaenoic acid (DHA) enhances nanodelivery of antiretroviral across the blood-brain barrier for treatment of HIV reservoir in brain. Journal of Controlled Release 2020; 328:696-709 (IF 8.66 for 2020), (5)
  33. Liu H, Zhou RH, Liu Y, Guo L, Wang X, Hu WH, Ho WZ. HIV Infection Suppresses TLR3 Activation-Mediated Antiviral Immunity in Microglia and Macrophages. Immunology. 2020 Feb 13. doi: 10.1111/imm.13181. Online ahead of print. PMID: 32053234 (IF 7.397 for 2020), (8)
  34. Bodnar B, DeGruttola A, Zhu Y, Lin Y, Zhang Y, Mo X, Hu WH*. Emerging role of NIK/IKK2-binding protein (NIBP)/trafficking protein particle complex 9 (TRAPPC9) in nervous system diseases. Transl Res. 2020 May 17:S1931-5244(20)30101-8. doi: 10.1016/j.trsl.2020.05.001. Online ahead of print. PMID: 32434006 (IF 7.012 for 2020), (9)
  35. Ye L, Li G, Goebel A, Raju AV, Kong F, Lv Y, Li K, Zhu Y, Raja S, He P, Li F, Mwangi SM, Hu WH, Srinivasan S. Caspase-11-mediated Enteric Neuronal Pyroptosis Underlies Western Diet-Induced Colonic Dysmotility. J Clin Invest. 2020 Jun 2:130176. doi: 10.1172/JCI130176. Online ahead of print. PMID: 32484462 (IF 14.808 for 2020), (23)
  36. Xu XQ, Liu Y, Zhang B, Liu H, Shao DD, Liu JB, Wang X, Zhou LN, Hu WH, Ho WZ. IL-22 suppresses HSV-2 replication in human cervical epithelial cells. Cytokine. 2019 Nov;123:154776. doi: 10.1016/j.cyto.2019.154776. Epub 2019 Jul 22. PMID: 31344598 (4)
  37. Li A, Sun Y, Drummer C 4th, Lu Y, Yu D, Zhou Y, Li X, Pearson SJ, Johnson C, Yu C, Yang WY, Mastascusa K, Jiang X, Sun J, Rogers T, Hu WH, Wang H, Yang X. Increasing Upstream Chromatin Long-Range Interactions May Favor Induction of Circular RNAs in LysoPC-Activated Human Aortic Endothelial Cells. Front Physiol. 2019 Apr 18;10:433. (12)
  38. Putatunda R, Zhang Y, Li F, Fagan PR, Zhao H, Ramirez SH, Praticò D, Barbe MF, Hu WH*. Sex-specific neurogenic deficits and neurocognitive disorders in middle-aged HIV-1 Tg26 transgenic mice. Brain Behav Immun. 2019 Apr 16;. doi: 10.1016/j.bbi.2019.04.029. (11)
  39. Putatunda R, Ho WZ, Hu WH*. HIV-1 and Compromised Adult Neurogenesis: Emerging Evidence for a New Paradigm of HAND Persistence. AIDS Rev. 2019;21(1):11-22. (4)
  40. Shen H, Wu N, Nanayakkara G, Fu H, Yang Q, Yang WY, Li A, Sun Y, Drummer Iv C, Johnson C, Shao Y, Wang L, Xu K, Hu WH, Chan M, Tam V, Choi ET, Wang H, Yang X. Co-signaling receptors regulate T-cell plasticity and immune tolerance. Front Biosci (Landmark Ed). 2019;24:96-132. (29)
  41. Putatunda R, Bethea JR, Hu WH*. Potential immunotherapies for traumatic brain and spinal cord injury. Chinese Journal of Traumatology 2018; 21(3):125-136. (28)
  42. Putatunda R, Zhang Y, Li F, Yang XF, Barbe MF, Hu WH*. Adult neurogenic deficits in HIV-1 Tg26 transgenic mice. J Neuroinflammation. 2018; 15(1):287. (16)
  43. Zhang Y, Arango G, Li F, Xiao X, Putatunda R, Yu J, Yang XF, Wang H, Watson LT, Zhang L, Hu WH*. Comprehensive off-target analysis of dCas9-SAM-mediated HIV reactivation via long noncoding RNA and mRNA profiling. BMC medical genomics. 2018; 11(1):78.(12)
  44. Xiao X, Putatunda R, Zhang Y, Soni P, Li F, Zhang T, Xin MY, Luo JJ, Bethea JR, Cheng Y, Hu WH*. Lymphotoxin β receptor-mediated NFκB signaling promotes glial lineage differentiation and inhibits neuronal lineage differentiation in mouse brain neural stem/progenitor cells. J Neuroinflammation 2018, 15(1):49. (14)
  45. Xu K, Yang WY, Nanayakkara GK, Shao Y, Yang F, Hu WH, Choi ET, Wang H and Yang XF. GATA3, HDAC6, and BCL6 Regulate FOXP3+ Treg Plasticity and Determine Treg Conversion into Either Novel Antigen-Presenting Cell-Like Treg or Th1-Treg. Front. Immunol. 2018; 9:45. (44)
  46. Zhu Y, Shui M, Liu X, Hu WH, Wang Y. Increased autophagic degradation contributes to the neuroprotection of hydrogen sulfide against cerebral ischemia/reperfusion injury. Metabolic brain disease. 2017; 32(5):1449-1458. (19)
  47. Hou W, Cruz-Cosme R, Armstrong N, Obwolo LA, Wen F, Hu WH, Luo MH, Tang Q. Molecular cloning and characterization of the genes encoding the proteins of Zika virus. Gene. 2017; 628:117-128. (44)
  48. Li YF, Nanayakkara G, Sun Y, Li X, Wang L, Cueto R, Shao Y, Fu H, Johnson C, Cheng J, Chen X, Hu WH, Yu J, Choi ET, Wang H, Yang XF. Analyses of caspase-1-regulated transcriptomes in various tissues lead to identification of novel IL-1β-, IL-18- and sirtuin-1-independent pathways. Journal of hematology & oncology. 2017; 10(1):40. (44)
  49. Zhu Y, Lin Y, Liu X, Hu WH, Wang Y. Identification of AcAP5 as a novel factor Xa inhibitor with both direct and allosteric inhibition. Biochem Biophys Res Commun. 2017; 483(1):495-501. (3)
  50. Yin C, Zhang T, Qu X, Zhang Y, Putatunda R, Xiao X, Li F, Xiao W, Zhao H, Dai S, Qin X, Mo X, Young W-B, Khalili K, Hu W, In vivo excision of HIV-1 provirus by saCas9 and multiplex sgRNAs in animal models, Molecular Therapy, doi:10.1016/j.ymthe.2017.03.012 (Full-text)
  51. Zhang Y, Li F, Xiao X, Deng W, Yin C, Zhang T, Murthy KS, Hu W*. Regulator of G protein signaling 4 is a novel target of GATA-6 transcription factor. Biochem Biophys Res Commun. 2016 Oct 13. pii: S0006-291X(16)31688-6. doi: 10.1016/j.bbrc.2016.10.024. (Full-text)
  52. D’Rozario M, Zhang T, Waddell EA, Zhang YG, Sahin C, Sharoni M, Hu T, Naya M, Kutty K, Lieb F, Hu WH*, and Marenda DR. Type I bHLH proteins Daughterless and TCF4 restrict neurite branching and synapse formation by repressing Neurexin in postmitotic neurons. Cell Reports, 2016 Apr 12;15(2):386-97 (Full-text)
  53. Feng D, Shen D, Liu F, Ohtake Y, Zhou A, Wang H, Zhang Y, Kearns A, Peng X, Zhu F, Hayat U, Li M, He Y, Xu M, Zhao C, Cheng M, Zhang L, Wang H, Yang X, Ju C, Bryda EC, Gordon J, Khalili K, Hu WH, Li S, Qin X and Gao B. Cre-inducible human CD59 mediates rapid cell ablation after intermedilysin administration. J Clinical Investigation 2016 Jun 1;126(6):2321-33 (Full-text)
  54. Yin CR, Zhang T, Li F, Yang F, Putatunda R, Young WB, Khalili K, Hu WH*, and Zhang YG. Functional screening of guide RNAs targeting the regulatory and structural HIV-1 viral genome for a cure of AIDS. AIDS, 2016 May 15;30(8):1163-74 (Full-text)
  55. Kaminski R, Chen Y, Fischer T, Tedaldi E, Napoli A, Zhang Y, Karn J, Hu WH*, Khalili K. Elimination of HIV-1 Genomes from Human T-lymphoid Cells by CRISPR/Cas9 Gene Editing. Scientific Reports, 2016 Mar 4;6:22555. (Full-text)
  56. Zhang YG, Li F, Wang H, Yin CY, Huang J, Mahavadi S, Murthy KS, Hu WH*. Immune/Inflammatory Response and Hypocontractility of Rabbit Colonic Smooth Muscle After TNBS-Induced Colitis. Dig Dis Sci. 2016; 61(7):1925-40 (Full-text)
  57. McCaffrey J, Sibert J, Zhang B, Zhang Y, Hu WH, Riethman H, Xiao M. CRISPR-CAS9 D10A nickase target-specific fluorescent labeling of double strand DNA for whole genome mapping and structural variation analysis.Nucleic Acids Res. 2016 Jan 29;44(2):e11. (Full-text)
  58. Zhang YG, Yin CR, Zhang T, Li F, Yang WS, Kaminski R, Fagan P, Putatunda R, Young WB, Khalili K, and Hu WH*. CRISPR/gRNA-directed synergistic activation mediator (SAM) induces specific, persistent and robust reactivation of the HIV-1 latent reservoir. Scientific Reports, 2015 Nov 5; 5:16277. (Full-text)
  59. Zhang YG, Liu S, Wang H, Yang WS, Li F, Yang F, Yu DH, Ramsey FV, Tuszyski GP, Hu WH*. Elevated NIBP/TRAPPC9 mediates tumorigenesis of cancer cells through NFκB signaling. OncoTarget 2015 Mar 20;6(8):6160-78 (Full-text)
  60. Hu WH*, Kaminski R, Yang F, Zhang YG, Cosentino L, Li F, Luo B,  Alvarez-Carbonell D, Garcia Y, Karn J, Mo XM, and Khalili K. RNA-directed gene editing specifically eradicates latent and prevents new HIV-1 infection. PNAS 2014; 111(31):11461-6. (Full-text)
  61. Zhang YG, Bitner D, Pontes A, Li F, Liu S, Wang H, Yang F, Adhikari S, Gordon J, Srinivasan S, Hu WH*. Expression and function of NIK- and IKK2-binding protein (NIBP) in mouse enteric nervous system. Neurogastroenterology Motility 2014; 26(1):77-97. (Full-text)
  62. Zhang, Y. and Hu WH*. Mouse Enteric Neuronal Cell Culture. Neuronal Cell Culture. S. Amini and M. K. White (Ed), ISBN: 978-1-62703-639-9, Humana Press, 2013. DOI: 10.1007/978-1-62703-640-5_6. Method in Molecular Biology 2013; 1078: 55-63 (Full-text)
  63. Pontes A, Zhang Y and Hu WH*. Novel functions of GABA signaling in adult neurogenesis. Front Biol 2013; DOI 10.1007/s11515-013-1270-2 (Review)
  64. Zhang Y and Hu WH*. NFκB signaling directs neuronal fate decision. In: Wislet-Gendebien S (ed): Trends in Cell Signaling Pathways in Neuronal Fate Decision. InTech 2012, ISBN 980-953-307-601-5 (Full-text)
  65. Zhang Y and Hu WH. NFkB signaling regulates embryonic and adult neurogenesis. Front Biol 2012; DOI 10.1007/s11515-012-1233-z. (Full-text)
  66. Zhang Y, Liu J, Yao S, Li F, Xin L, Lai M, Bracchi-Ricard V, Xu H, Yen W, Meng W, Liu S, Yang L, Karmally S, Zhu H, Gordon J, Khalili K, Srinivasan S, Bethea JR, Mo X, Hu WH. Nuclear factor kappa B signaling initiates early differentiation of neural stem cells. Stem Cells 2012;30:510-524. (IF:7.871)(cited by 1) (Full-text)
  67. Zhang Y, Li F, Liu S, Wang H, Mahavadi S, Murthy KS, Khalili K, Hu WH. MEKK1-MKK4-JNK-AP1 Pathway Negatively Regulates Rgs4 Expression in Colonic Smooth Muscle Cells. PLoS One 2012;7:e35646. (IF:4.411) (Full-text)
  68. Sun D, Gugliotta M, Rolfe A, Reid W, McQuiston AR, Hu WH, Young H. Sustained survival and maturation of adult neural stem/progenitor cells after transplantation into the injured brain. J Neurotrauma 2011;28:961-972. (IF:3.426) (Full-text)
  69. Li F, Murthy KS, Khalili K, Hu WH. Cloning and characterization of rabbit Rgs4 promoter in gut smooth muscle. Gene 2010;451:45-53. (IF:2.266) (cited by 3) (Full-text)
  70. Li F, Hu DY, Liu S, Mahavadi S, Yen W, Murthy KS, Khalili K, Hu WH. RNA-binding protein HuR regulates RGS4 mRNA stability in rabbit colonic smooth muscle cells. Am J Physiol Cell Physiol 2010;299:C1418-1429. (IF:3.817) (cited by 3) (Full-text)
  71. Kuang X, Hu WH, Yan M, Wong PK. Phenylbutyric acid suppresses protein accumulation-mediated ER stress in retrovirus-infected astrocytes and delays onset of paralysis in infected mice. Neurochem Int 2010;57:738-748. (IF:3.601) (cited by 2) (Full-text)
  72. Hu WH, Li F, Mahavadi S, Murthy KS. Upregulation of RGS4 expression by IL-1beta in colonic smooth muscle is enhanced by ERK1/2 and p38 MAPK and inhibited by the PI3K/Akt/GSK3beta pathway. Am J Physiol Cell Physiol 2009;296:C1310-1320. (IF:3.817) (cited by 11) (Full-text)
  73. Hu WH, Li F, Mahavadi S, Murthy KS. Interleukin-1beta up-regulates RGS4 through the canonical IKK2/IkappaBalpha/NF-kappaB pathway in rabbit colonic smooth muscle. Biochem J 2008;412:35-43. (IF:5.016) (cited by 15) (Full-text)
  74. Bracchi-Ricard V, Brambilla R, Levenson J, Hu WH, Bramwell A, Sweatt JD, Green EJ, Bethea JR. Astroglial nuclear factor-kappaB regulates learning and memory and synaptic plasticity in female mice. J Neurochem 2008;104:611-623. (IF:4.337) (cited by 19) (Full-text)
  75. Zhou H, Jarujaron S, Gurley EC, Chen L, Ding H, Studer E, Pandak WM, Jr., Hu WH, Zou T, Wang JY, Hylemon PB. HIV protease inhibitors increase TNF-alpha and IL-6 expression in macrophages: involvement of the RNA-binding protein HuR. Atherosclerosis 2007;195:e134-143. (IF:4.086) (cited by 21) (Full-text)
  76. Song Y, Wilkins P, Hu WH, Murthy KS, Chen J, Lee Z, Oyesanya R, Wu J, Barbour SE, Fang X. Inhibition of calcium-independent phospholipase A2 suppresses proliferation and tumorigenicity of ovarian carcinoma cells. Biochem J 2007;406:427-436. (IF:5.016) (cited by 33) (Full-text)
  77. Hu WH, Mahavadi S, Li F, Murthy KS. Upregulation of RGS4 and downregulation of CPI-17 mediate inhibition of colonic muscle contraction by interleukin-1beta. Am J Physiol Cell Physiol 2007;293:C1991-2000. (IF:3.817) (cited by 13) (Full-text)
  78. Yan D, Li F, Hall ML, Sage C, Hu WH, Giallourakis C, Upadhyay G, Ouyang XM, Du LL, Bethea JR, Chen ZY, Yajnik V, Liu XZ. An isoform of GTPase regulator DOCK4 localizes to the stereocilia in the inner ear and binds to harmonin (USH1C). J Mol Biol 2006;357:755-764. (IF:4.008) (cited by 16) (Full-Text)
  79. Huang J, Mahavadi S, Sriwai W, Hu WH, Murthy KS. Gi-coupled receptors mediate phosphorylation of CPI-17 and MLC20 via preferential activation of the PI3K/ILK pathway. Biochem J 2006;396:193-200. (IF:5.016) (cited by 46) (Full-Text)
  80. Hu WH, Mahavadi S, Huang J, Li F, Murthy KS. Characterization of S1P1 and S1P2 receptor function in smooth muscle by receptor silencing and receptor protection. Am J Physiol Gastrointest Liver Physiol 2006;291:G605-610. (IF:3.522) (cited by 21) (Full-Text)
  81. Hu WH, Huang J, Mahavadi S, Li F, Murthy KS. Lentiviral siRNA silencing of sphingosine-1-phosphate receptors S1P1 and S1P2 in smooth muscle. Biochem Biophys Res Commun 2006;343:1038-1044. (IF:2.595) (cited by 17) (Full-Text)
  82. Hu WH, Pendergast JS, Mo XM, Brambilla R, Bracchi-Ricard V, Li F, Walters WM, Blits B, He L, Schaal SM, Bethea JR. NIBP, a novel NIK and IKK(beta)-binding protein that enhances NF-(kappa)B activation. J Biol Chem 2005;280:29233-29241. (IF:5.328) (cited by 39) (Full-Text)
  83. Brambilla R, Bracchi-Ricard V, Hu WH, Frydel B, Bramwell A, Karmally S, Green EJ, Bethea JR. Inhibition of astroglial nuclear factor kappaB reduces inflammation and improves functional recovery after spinal cord injury. J Exp Med 2005;202:145-156. (IF:14.776) (cited by 126) (Full-Text).
  84. Hu WH, Mo XM, Walters WM, Brambilla R, Bethea JR. TNAP, a novel repressor of NF-kappaB-inducing kinase, suppresses NF-kappaB activation. J Biol Chem 2004;279:35975-35983. (IF:5.328) (cited by 29) (Full-Text),
  85. Hu WH, Walters WM, Xia XM, Karmally SA, Bethea JR. Neuronal glutamate transporter EAAT4 is expressed in astrocytes. Glia 2003;44:13-25. (IF:5.186) (cited by 34) (Full-Text).
  86. Hu WH, Hausmann ON, Yan MS, Walters WM, Wong PK, Bethea JR. Identification and characterization of a novel Nogo-interacting mitochondrial protein (NIMP). J Neurochem 2002;81:36-45. (IF:4.337) (cited by 35) (Full-Text)
  87. Hausmann ON, Hu WH, Keren-Raifman T, Witherow DS, Wang Q, Levay K, Frydel B, Z Slepak V, R Bethea JR. Spinal cord injury induces expression of RGS7 in microglia/macrophages in rats. Eur J Neurosci 2002; 15(4):602-612. (IF:3.658) (cited by 11) (Full-Text).
  88. Qiang WA, Sun L, Hu WH, Zuo P, Ren MF and Liu JS. Effects of high dose of dynorphin on NMDA receptor and NOS activities in spinal cord of rats. Acta Academiae Medicinae Sinicae 2000; 22(2):134-138. (Full-Text)
  89. Hu WH, Liu N, Li F, Qiang WA, LiaoWH and Ren MF.  Effects of kappa-opioid receptor on dynorphin-induced spinal cord injury. Chin J Traumatol 2000; 16(5): 286-288. 
  90. Hu WH, Qiang WA, Li F, Liu N, Wang GQ, Wang HY, Wan XS, Liao WH, Liu JS, Jen MF. Constitutive and inducible nitric oxide synthases after dynorphin-induced spinal cord injury. J Chem Neuroanat 2000;17:183-197. IF:2.121) (cited by 17) (Full-Text)
  91. Hu WH, Johnson H, Shu HB. Activation of NF-kappaB by FADD, Casper, and caspase-8. J Biol Chem 2000;275:10838-10844. (IF:5.328) (cited by 231) (Full-Text)
  92. Zeng C, Zhu Z, Hu WH, Liu G, Zhu S, Zhou Y, Shi W. Value of sublingual isosorbide dinitrate before isoproterenol tilt test for diagnosis of neurally mediated syncope. Am J Cardiol 1999;83:1059-1063. (IF:3.681) (cited by 26) (Full-Text)
  93. Shu HB, Hu WH, Johnson H. TALL-1 is a novel member of the TNF family that is down-regulated by mitogens. J Leukoc Biol 1999;65:680-683. (IF:4.626) (cited by 336) (Full-Text)
  94. Hu WH, Li F, Qiang WA, Liu N, Wang GQ, Xiao J, Liu JS, Liao WH, Jen MF. Dual role for nitric oxide in dynorphin spinal neurotoxicity. J Neurotrauma 1999;16:85-98. (IF:3.426) (cited by 24) (Full-Text)
  95. Hu WH, Johnson H, Shu HB. Tumor necrosis factor-related apoptosis-inducing ligand receptors signal NF-kappaB and JNK activation and apoptosis through distinct pathways. J Biol Chem 1999;274:30603-30610. (IF:5.328) (cited by 211) (Full-Text)
  96. Hu WH, Yang HF, Li F, Qiang WA, Sun XJ, Liu N, Wan XST, Liu JS and Ren MF. Increases of inducible nitric oxide synthase activity and mRNA expression in rat spinal cord after dynorphin neurotoxicity. Chin J Pathophysiol 1999; 15(3):217-221. (Full-Text)
  97. Li F, Hu WH, Liu N, Qiang WA, Sun XJ,  Wan XST, Liu JS and Jen MF. Role of neuronal nitric oxide synthase in dynorphin spinal neurotoxicity and analgesia in rats. Nat. Med. J. Chin 1999; 79(3):217-220 (Full-Text)
  98. Hu WH, Zhang CH, Yang HF, Zheng YF, Liu N, Sun XJ and Jen MF. Dualistic effect of dynorphin on high potassium-induced increase of intracellular free calcium concentration in cultured rat spinal neurons. Chin J Pharmacol Toxicol 1998; 12(1):32-35
  99. Hu WH, Zhang CH, Yang HF, Zheng YF, Liu N, Sun XJ, Jen J, Jen MF. Mechanism of the dynorphin-induced dualistic effect on free intracellular Ca2+ concentration in cultured rat spinal neurons. Eur J Pharmacol 1998;342:325-332. (IF:2.737) (cited by 17) (Full-Text)
  100. Hu WH, Liu N, Sun XJ, Jen J, Yang HF and Jen MF. L-NAME aggravates dynorphin-induced spinal cord injury in rats. Chin J Neurosci 1997; 4(3):115-119
  101. Li FC, Zuo PP, Hu WH, Liu N, Jen MF. Glutamate involvement in rats with spinal cord injury induced by dynorphin A(1-17). Chin J. Rehabil. Theory and Practice 1997; 3:6-9.
  102. Hu WH. [Effects of dynorphin A1-17 on the activities, immunoreactivities and mRNA expression of cNOS and iNOS in rat spinal cord and their mechanisms]. Sheng Li Ke Xue Jin Zhan 1997;28:45-48.
  103. Hu WH, Lee FC, Wan XS, Chen YT, Jen MF. Dynorphin neurotoxicity induced nitric oxide synthase expression in ventral horn cells of rat spinal cord. Neurosci Lett 1996;203:13-16. (IF:2.055) (cited by 18) (Full-Text)
  104. Hu WH, Sun XJ, Wan XST, Liu JS and Jen MF. Intrathecal administration of NOS inhibitor L-NAME produced algesia, analgesia and paralysis in rat. Chin Pharmacol Bull 1996; 12(4):309-313
  105. Li F, Hu WH, Liao WH and Jen MF. Nitric oxide mediates NMDA neurotoxicity in rat primary spinal culture. Chin J Neurosci 1995; P245
  106. Hu WH, Yang HW, Wang YJ and Liao WH. Segmental distribution of electrocytes and water in spinal cord after ischemia-reperfusion injury in conscious rabbits. Acta Academiae Medicinae Militaris Tertiae  1995; 17(4):315-317
  107. Li FC, Sun XJ, Hu WH and Jen MF. Intrathecal coadministration of kappa opioid receptor agonists and NMDA receptor antagonist induced synergetic analgesia in rat. Acta Pharmaceutia Sinica 1994; 29(12):881-886
  108. Hu WH, Yang HW and Liao WH. The effects of neurotransmitter and non-neurotransmitter amino acids in secondary injury after spinal cord ischemia in awake rabbits. Acta Academiae Medicinae Militaris Tertiae  1994; 16(3):170-4
  109. Hu WH, Yang HW, Wang YJ and Liao WH. The effect of ion changes and edema formation during secondary injury following spinal cord ischemia in awaken rabbit. Chin J Pathophysiol 1994;10(6):659
  110. Hu WH, Yang HW, Lu XB and Liao WH.  Neurobehavioral outcome of spinal cord delayed postischemic injury in awaken rabbits. Chin J Pathophysiol 1993; 9(4):483
  111. Yang HW, Hu WH, Ding ZM and Liu YB. Changes of spinal cord blood flow after ventral spinal cord injury in rats. Chinese J Neurosurg 1991; 7(2):87
  112. Hu WH, Liu YB, Yang CQ, et al. Measurement of blood flows to gray and white matter of segmental spinal cord with radioactive biomicrosphere technique.  Chin J Neurosurg 1990

Patents

  1. Chimeric capsid recombinant adeno-associated virus with BBB penetration and microglia targeting (AAV-BM). PCT(US24/29057), 5/13/2024
  2. Oligonucleotides and viral untranslated region (UTR) for increasing expression of target genes and proteins. PCT (US22/36367), 7/7/2022
  3. Methods of specifically labeling nucleic acids using CRISPR/Cas9  2016
  4. Compositions and Methods for Specific Reactivation of HIV Latent Reservoir           US20180073018A1          2015; Date issued 3/15/2018
  5. Methods and Compositions for RNA-Guided Treatment of HIV Infection  WO2015031775 A1    8/29/2014; US9925248B2 Date issued 5/29/2018; Licensed to Excision BioTherapeutics.
  6. RNA guided eradication of human JC virus and other polyomaviruses  WO2016070070 A1                           2013
  7. Use of NIBP polypeptides US2010/052302      2011 WO2011046922 A1

 

Genebank Database

1.   DQ120011 Oryctolagus cuniculus regulator of G-protein signalling 4 (RGS4) mRNA, 5' UTR and complete cds.  gi|74027175|gb|DQ120011.1|[74027175]

2.   AY630620  Mus musculus NIK and IKKbetta-binding protein (Nibp) mRNA, complete cds
gi|54289214|gb|AY630620.1|[54289214]

3.   AY630619  Homo sapiens NIK and IKKbetta-binding protein (NIBP) mRNA, partial cds
gi|54289212|gb|AY630619.1|[54289212]

4.   AF463496 Homo sapiens NIK-associated protein mRNA, complete cds. gi|27462964|gb|AF463496.1|[27462964]

5.   AF336862 Mus musculus NOGO-interacting mitochondrial protein (NIMP) mRNA, complete cds
gi|14522883|gb|AF336862.1|[14522883]

6.   AF336861 Homo sapiens NOGO-interacting mitochondrial protein (NIMP) mRNA, complete cds
gi|14522881|gb|AF336861.1|AF336861[14522881]

7.   AF136294 Homo sapiens TNF and ApoL related ligand TALL-2 (TALL2) mRNA, complete cds
gi|4761613|gb|AF136294.1|AF136294[4761613]

8.   AF136293 Homo sapiens TNF and ApoL related ligand TALL-1 (TALL1) mRNA, complete cds
gi|4761611|gb|AF136293.1|AF136293[4761611]

 

 

VCU

TU SOM• CMDR •SFN • AGA • DDW • ASBMB

 

This site was last updated 8/28/2024